Cambridge Institute of Therapeutic Immunology & Infectious DiseaseEnzymes are naturally occurring biological catalysts, which enable the chemical transformations required for our bodies to function – from translating the genetic code into proteins, right through to digesting food. Although most enzymes are proteins, some of these crucial reactions are catalysed by RNA, a chemical cousin of DNA, which can fold into enzymes known […]
Referrals to long COVID clinic fell by 79% following roll-out of the vaccine
According to the Office of National Statistics, in July this year an estimated 2 million people in the UK were living with self-reported long COVID – that is, symptoms continuing for more than four weeks after their first suspected coronavirus (COVID-19) infection. Patients report symptoms including fatigue, muscle aches, memory problems and shortness of breath […]
Modis Group – Science Advances
Executive summary The Modis Group has found an endogenous retrovirus in hookworm with an envelope protein with a fold remarkably similar to phlebovirus envelope proteins. This study, recently published in Science Advances, shows that reverse-transcribing RNA viruses have the potential to replace their usual envelope protein with a fusion protein from a genetically unrelated RNA […]
Modis Lab – A mutation in MDA5 associated with inherited autoinflammatory disease prevents structural discrimination between viral and cellular RNA
A mutation in MDA5 associated with inherited autoinflammatory disease prevents structural discrimination between viral and cellular RNA MDA5 is one of the most important and conserved immune sensors of viral RNA. As such, MDA5 is the primary immune sensor for SARS-CoV-2 and many other viruses. More than 30 genetic variants in the gene encoding MDA5 […]
The microbiologist tackling humanity’s next biggest killer
Spread of Delta SARS-CoV-2 variant driven by combination of immune escape and increased infectivity
Upgrading PPE for staff working on COVID-19 wards cut hospital-acquired infections dramatically
Key mutations in Alpha variant enable SARS-CoV-2 to overcome evolutionary weak points
Ravi Gupta elected to the Academy of Medical Sciences
Single-cell transcriptomics and proteomics profiling of COVID19 samples reveals immune and HSPC changes that are differentially associated with disease severity
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