I study the communication of innate immune cells with their environment and am particularly interested in G protein-coupled receptors (GPCRs) and the cellular consequences of their activation. The genetic locus of the orphan GPCR GPR35 and a coding variant of the receptor have been associated with risk for inflammatory bowel disease and primary sclerosing cholangitis. However, GPR35’s endogenous, relevant ligands and its function remain enigmatic. Via specific, consciously designed and specific lipopeptides, I aim to modulate GPR35 function to reveal its biological function and will investigate whether its genetic dysfunction can be corrected chemically via pharmacological manipulation of the risk variant.
Schneditz G, Elias JE … Kaneider NC; GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump. Science Signaling 2019. DOI: 10.1126/scisignal.aau9048
Wieser V, Adolph TE;Reversal of murine alcoholic steatohepatitis by pepducin-based functional blockade of interleukin-8 receptors. Gut 2017. DOI: 10.1136/gutjnl-2015-310344
Tressel SL, Kaneider NC; A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis. EMBO Molecular Medicine 2011. DOI: 10.1002/emmm.201100145
Kaneider N et al; ‘Role reversal’ for the receptor PAR1 in sepsis-induced vascular damage. Nature Immunology 2007. DOI: 10.1038/ni1525
Kaneider N et al. Reversing systemic inflammatory response syndrome with chemokine receptor pepducins. Nature Medicine 2005. DOI: 10.1038/nm1245