We study the communication of innate immune cells with their environment and are particularly interested in G protein coupled receptors (GPCRs) and the cellular consequences of their activation. The genetic locus of the orphan GPCR GPR35 and a coding variant of the receptor have been associated with risk for inflammatory bowel disease and primary sclerosing cholangitis. However, GPR35’s endogenous, relevant ligands and the receptor’s function remain enigmatic.
We recently discovered that GPR35 regulates the cell’s ion homeostasis, its metabolic and proliferative activity by interacting with the sodium-potassium pump.
Via specific, consciously designed and specific lipopeptides (‘pepducins’), we modulate GPR35 function and investigate whether its genetic dysfunction can be corrected chemically via pharmacological manipulation of the risk variant.
Gut. 2021 Mar 23:gutjnl-2020-323363. doi: 10.1136/gutjnl-2020-323363.
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