Genetic studies have successfully identified many regions of the human genome that increase an individual’s risk of autoimmune or inflammatory disease, but the molecular mechanisms that underpin these associations – and hence the reason they alter disease susceptibility – remain largely unknown. Our group is interested in uncovering the biology responsible for genetic associations in immune-mediated disease by combining genetics, genomics, molecular biology, and immunology-based approaches. We have a particular focus on the non-coding genome, including enhancers and non-coding RNA, and the role that they might play in regulating immune responses. Our goal is to not only shed new light on pathways involved in disease pathogenesis but to also provide novel therapeutic opportunities. Other interests include better understanding the genetic and biological determinants of prognosis in autoimmune, inflammatory and infectious diseases – as distinct from those pathways that drive disease development. James Lee currently holds a Wellcome Trust Intermediate Clinical Fellowship, and has recently spent 2 years at Harvard as part of this. He is also a member of the UK and International IBD Genetics Consortia.
Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn’s disease.
Lee JC* †, Biasci D*, Roberts R, Gearry RB, Mansfield JC, Ahmad T, Prescott NJ, Satsangi J, Wilson DC, Jostins L, Anderson CA; UK IBD Genetics Consortium., Traherne JA, Lyons PA, Parkes M, Smith KGC†. [* denotes joint first authors, † denotes co-corresponding authors]. Nature Genetics 2017. 49: 262-268
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
de Lange KM*, Moutsianas L*, Lee JC*, Lamb CA, Luo Y, Kennedy NA, Jostins L, Rice DL, Gutierrez-Achury J, Ji SG, Heap G, Nimmo ER, Edwards C, Henderson P, Mowat C, Sanderson J, Satsangi J, Simmons A, Wilson DC, Tremelling M, Hart A, Mathew CG, Newman WG, Parkes M, Lees CW, Uhlig H, Hawkey C, Prescott NJ, Ahmad T, Mansfield JC, Anderson CA, Barrett JC. [* denotes joint first authors]. Nature Genetics 2017. 49: 256-261
In vivo characterization of Linc-p21 reveals functional cis-regulatory DNA elements.
Groff AF, Sanchez-Gomez DB, Soruco MML, Gerhardinger C, Barutcu AR, Li E, Elcavage L, Plana O, Sanchez LV, Lee JC, Sauvageau M, Rinn JL. Cell Reports 2016. 23;16(8):2178-86.
Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway.
Lee JC, Espéli M, Anderson CA, Linterman MA, Pocock JM, Williams NJ, Roberts R, Viatte S, Fu B, Peshu N, Hien TT, Phu NH, Wesley E, Edwards C, Ahmad T, Mansfield JC, Gearry R, Dunstan S, Williams TN, Barton A, Vinuesa CG, UK IBD Genetics Consortium, Parkes M, Lyons PA, Smith KGC. Cell 2013. 155(1):57-69.