Cambridge Institute of Therapeutic Immunology & Infectious DiseaseExecutive summary The Modis Group has found an endogenous retrovirus in hookworm with an envelope protein with a fold remarkably similar to phlebovirus envelope proteins. This study, recently published in Science Advances, shows that reverse-transcribing RNA viruses have the potential to replace their usual envelope protein with a fusion protein from a genetically unrelated RNA […]
Modis Lab – A mutation in MDA5 associated with inherited autoinflammatory disease prevents structural discrimination between viral and cellular RNA
A mutation in MDA5 associated with inherited autoinflammatory disease prevents structural discrimination between viral and cellular RNA MDA5 is one of the most important and conserved immune sensors of viral RNA. As such, MDA5 is the primary immune sensor for SARS-CoV-2 and many other viruses. More than 30 genetic variants in the gene encoding MDA5 […]
The microbiologist tackling humanity’s next biggest killer
Spread of Delta SARS-CoV-2 variant driven by combination of immune escape and increased infectivity
Upgrading PPE for staff working on COVID-19 wards cut hospital-acquired infections dramatically
Key mutations in Alpha variant enable SARS-CoV-2 to overcome evolutionary weak points
Ravi Gupta elected to the Academy of Medical Sciences
Single-cell transcriptomics and proteomics profiling of COVID19 samples reveals immune and HSPC changes that are differentially associated with disease severity
Infographics and risk factors associated with seroprevalence of SARS-CoV-2 antibodies in HCWs
As a component of our COVID research we conducted a seroepidemiology study to measure exposure to SARS-CoV-2 at Addenbrookes hospital. The work was lead by Dr Daniel Cooper, Dr Sara Lear, Prof Ian Goodfellow and Prof Stephen Baker in collaboration between the Hospital and the University. The work, A prospective study of risk factors associated […]
Genomics study identifies routes of transmission of coronavirus in care homes
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