Research Interests

Our laboratory environment emphasises intellectual rigour but with a flair for innovation and creativity. Our laboratory’s research is strongly focused on using genetics to discover genes involved in various biological systems, using somatic mutagenesis in mice to discover cancer genes and genetic screens in ES cells in culture. Our laboratory is an active and successful training environment for postdoctoral and clinical fellows and alumni include 22 independent PIs in 6 countries of whom 10 are full professors, or equivalent.

Allan Bradley is also a serial entrepreneur, establishing several biotechnology companies. While in the USA he founded two companies; Lexicon Pharmaceuticals Inc. is publicly traded while Spectral Genomics Inc. was acquired. In 2010 he founded Kymab Ltd., which now employs more than 80 scientists. Many of Allan’s trainees have joined these spin-outs.

Key Publications

Boroviak K, Fu B … Bradley A. Revealing hidden complexities of genomic rearrangements generated with Cas9. Scientific Reports 2017. DOI: 10.1038/s41598-017-12740-6

Martin J, Ponstingl H … Bradley A;Comprehensive annotation and evolutionary insights into the canine (Canis lupus familiaris) antigen receptor loci. Immunogenetics 2018. DOI: 10.1007/s00251-017-1028-0

Dovey OM, Bradley A … Vassiliou GS. Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia. Blood 2017. DOI: 10.1182/blood-2017-01-760595

Metzakopian E, Strong A … Bradley A. Enhancing the genome editing toolbox: genome wide CRISPR arrayed libraries. Scientific Reports 2017. DOI: 10.1038/s41598-017-01766-5